Cerebrospinal fluid C-reactive protein - A point of care test in the diagnosis of bacterial meningitis

  • Sivasambo Kalpana
  • Dorairaj Priyadharishini
Keywords: Bacterial meningitis, Cerebrospinal fluid - C reactive protein, Point of care test

Abstract

Background: Bacterial meningitis is a significant life-threatening illness during infancy and childhood. Delay in distinguishing
bacterial from viral or other aseptic meningoencephalitis may have irrevocable consequences. A typical case of pyogenic meningitis
without prior antibiotics may not create any diagnostic problems, but prior treatment with inappropriate and inadequate antibiotics
may cause sufficient alteration in biochemistry and cytology of cerebrospinal fluid (CSF), and organisms may not get isolated from
blood or CSF culture. Objective: C-reactive protein in CSF (CSF-CRP) has been reported to be one of the most reliable and early
indices to differentiate bacterial from non-bacterial meningitis. This study was undertaken to evaluate the diagnostic significance
of CSF- CRP as an early indicator in the differentiation of bacterial from non-bacterial meningitis. Materials and Methods: This
descriptive study was done in children in the age group of 1 month to 12 years who were admitted with history and clinical features
suggestive of acute central nervous system infection. CSF was analyzed for macroscopic appearance, pleocytosis, proteins, and
sugar content, Grams and Ziehl

Published
2018-03-19
How to Cite
Kalpana, S., & Priyadharishini, D. (2018). Cerebrospinal fluid C-reactive protein - A point of care test in the diagnosis of bacterial meningitis. Indian Journal of Child Health, 5(3), 170-173. Retrieved from http://www.atharvapub.net/index.php/IJCH/article/view/832
Section
Original Articles