Study of acute phase reactants in children with sepsis, with special reference to C-reactive protein and procalcitonin

  • G R Rajashekara Murthy
  • R Pradeep
  • K S Sanjay
  • Vinay Kumar
  • S K Sreenivas
Keywords: Acute phase reactants, C-reactive protein, Procalcitonin, Sepsis

Abstract

Background: Several inflammatory markers have failed to meet the requirements for an early diagnosis of sepsis in children. Study
results and trends show that measurement of the combination of biochemical markers offers the best prospects for research on early
diagnosis of sepsis. Objectives: To evaluate the serum levels of C-reactive protein (CRP) and procalcitonin (PCT) as markers of early
sepsis in pediatric patients. Methods: All the hospitalized children aged more than 28 days with clinically suspected sepsis, as per the
definition given by International Pediatric Sepsis Consensus Conference, were selected. The patients were divided into two groups; one
with culture proven sepsis and the other with culture negative sepsis. CRP and PCT levels were measured at the time of admission and
48 h after admission. Results: A 40 patients were studied, out of that 15 had culture positive and 25 had culture negative sepsis. The
mean PCT level was significantly higher at admission than at 48 h after admission, and the mean CRP level was significantly lower at
admission than at 48 h after admission indicating PCT as early marker of sepsis. Conclusion: CRP and PCT levels have favorable test
performance in differentiating between culture positive and culture negative sepsis. PCT is earlier to rise compared to CRP and PCT is
best in predicting the severity followed by CRP.

Published
2017-11-29
How to Cite
Murthy, G. R., Pradeep, R., Sanjay, K., Kumar, V., & Sreenivas, S. (2017). Study of acute phase reactants in children with sepsis, with special reference to C-reactive protein and procalcitonin. Indian Journal of Child Health, 2(3), 118-121. Retrieved from http://www.atharvapub.net/index.php/IJCH/article/view/573
Section
Original Articles